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US 9,121,851 B2Granted
Modular point-of-care devices, systems, and uses thereof
AssigneeTheranos, Inc.
InventorsTammy Burd, Ian Gibbons, Elizabeth A. Holmes, Gary Frenzel, Anthony Joseph Nugent
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Abstract
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.
Claims31
A system for detection of a first analyte and a second analyte in a biological sample, comprising:
- i) cartridge comprising a housing carrying a plurality of movable assay units configured to run chemical reactions on portions of said biological sample, wherein said chemical reactions are configured to yield detectable signals indicative of the presence or absence of said first analyte and said second analyte in the biological sample, wherein said housing is configured to carry a plurality of reagent units;
- ii) a plurality of movable reagent units separate from said housing, said reagent units being filled with reagents for running said chemical reactions, wherein individual reagent units are calibrated with reference to corresponding assay units;
- iii) a pipette assembly configured to transport aliquots of fluid and to transport assay units, said pipette assembly comprising pipette heads configured to engage said assay units;
- and
- iv) a detection assembly for detecting said signals indicative of the presence or absence of said first and second analytes in the biological sample.
2 more elements
A system for detection of a first analyte and a second analyte in a biological sample, comprising:
- i) cartridge comprising a housing carrying an array of addressable assay units configured to run chemical reactions on portions of said biological sample, wherein said chemical reactions are configured to yield detectable signals indicative of the presence or absence of said first analyte and said second analyte in the biological sample, wherein said housing is configured to carry a plurality of reagent units;
- ii) a plurality of reagent units separate from said housing, said reagent units being filled with reagents for running said chemical reactions, wherein individual reagent units are calibrated with reference to corresponding individual addressable assay units, and individual reagent units are addressed to correspond to individual addressable assay units;
- iii) a pipette assembly configured to transport aliquots of fluid and to transport assay units, said pipette assembly comprising pipette heads configured to engage said assay units;
- and
- iv) a detection assembly for detecting said signals indicative of the presence or absence of said first and second analytes in the biological sample.
2 more elements
Dependencies are inferred from the claim text.