Treatment of bone-related cancers using placental stem cells
AssigneeAnthrogenesis Corporation
InventorsXiaokui Zhang, Shmuel Yaccoby, Sascha Abramson, Robert J. Hariri
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Abstract
Provided herein are methods of suppression of proliferation and growth of cells of bone-related cancers, e.g., multiple myeloma or chondrosarcoma cells, using placental cells, e.g., the placental stem cells described herein, and populations of such placental cells. Also provided herein are methods of treating individuals having cells of a bone-related cancer.
Claims10
An in vitro method of suppressing the proliferation of cells of a bone-related cancer, comprising contacting said cells of a bone-related cancer with a plurality of placental stem cells for a time sufficient for said placental stem cells to suppress proliferation of said cells of a bone-related cancer, as compared to a plurality of said cells of a bone-related cancer not contacted with placental stem cells, wherein said placental stem cells are CD34−, CD 10+, CD 105+ and CD200+ as detectable by flow cytometry, and are not trophoblasts, cytotrophoblasts or bone marrow-derived mesenchymal stem cells, and wherein said cells of a bone-related cancer are multiple myeloma cells, chondrosarcoma cells, osteosarcoma cells, Ewing sarcoma cells, chordoma cells, cells of a malignant fibrous histiocytoma of bone, or cells of a fibrosarcoma of bone not prostate cancer cells.
A method of treating a bone related cancer, comprising administering to a subject having a bone-related cancer a plurality of placental stem cells for a time sufficient for said placental stem cells to suppress proliferation of cells of said bone-related cancer,
- wherein said placental stem cells are CD34−, CD 10+, CD 105+ and CD200+ as detectable by flow cytometry, and are not trophoblasts, cytotrophoblasts or bone marrow-derived mesenchymal stem cells,
- and wherein said cells of a bone-related cancer are multiple myeloma cells, chondrosarcoma cells, osteosarcoma cells, Ewing sarcoma cells, chordoma cells, a malignant fibrous histiocytoma of bone, or a fibrosarcoma of bone.
Dependencies are inferred from the claim text.