Low-density magnesium-aluminum-silicate (MAS) microparticles for radiotherapy and/or radioimaging
AssigneeMo-Sci Corporation
InventorsDelbert E. Day, Yiyong He
Life of this patent
Estimating the term…
Abstract
This invention relates to low density radioactive magnesium-aluminum-silicate (MAS) microparticles that contain either samarium-yttrium, samarium, or lutetium as medical isotopes for radiotherapy and/or radioimaging.
Claims22
A radioactive low density microparticle for radioimaging or radiation therapy of a mammal comprising a biologically compatible magnesium-alumina-silicate glass microparticle having a density of about 3.0 g/cc or less said microparticle containing at least one beta or gamma radiation emitting isotope distributed substantially throughout the magnesium-alumina-silicate glass which emits a therapeutic intensity and amount of beta or gamma radiation, and a balance of elements selected from the group consisting of elements that do not become radioactive upon neutron irradiation and elements that have a half-life that is sufficiently short so that the elements do not emit a significant amount of beta or gamma radiation at the time of administration, the microparticle having a chemical durability such that subsequent to administration of the microparticle to the mammal, the microparticle will not release a significant amount of the radiation emitting radioisotope into the mammal's system;
- wherein the glass microparticle comprises 8-14 wt % MgO, 32-35 wt % Al2O3, and 47-52 wt % SiO2.
A method of obtaining a radiologic image of a patient's organ, comprising administering by catheter to an artery that feeds an organ of a patient a composition containing radioactive magnesium-alumina-silicate glass microparticles that contain samarium-153 or lutetium-177 as the medical isotope in a physiologically acceptable carrier, and obtaining the radiologic image of the patient's organ by capturing the radiation emitted by the samarium-153 or lutetium-177 using a suitable radionuclide imaging technique;
- wherein the glass microparticles comprise 8-14 wt % MgO, 32-35 wt % Al2O3, 47-52 wt % SiO2, and said samarium-153 or lutetium-177.
A method of administering radioactive magnesium-alumina-silicate glass microparticles that contain both samarium-153 as a radiodiagnostic medical isotope and yttrium-90 as a radiotherapeutic medical isotope to a patient in need thereof, comprising delivering by catheter to the hepatic artery of a patient a composition comprising radioactive magnesium-alumina-silicate glass microparticles that contain a radiodiagnostic amount of samarium-153 and a radiotherapeutic amount of yttrium-90, and a physiologically acceptable carrier;
- wherein the glass microparticles comprise 8-14 wt % MgO, 32-35 wt % Al2O3, 47-52 wt % SiO2, the radiodiagnostic amount of samarium-153, and the radiotherapeutic amount of yttrium-90.
Dependencies are inferred from the claim text.