Non-pathogenic serotype 4 fowl adenovirus (fadv-4) and viral vector thereof
AssigneeUniversity of Guelph
InventorsÉva Nagy, Bryan Griffin, Helena Grgic, Davor Ojkic
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Abstract
A high level replication fowl adenovirus (FAdV) isolate capable of reaching a viral titer of at least 3 log 10 is described. Said FAdV is a non-pathogenic strain of fowl adenovirus serotype 4, identified as FAdV-4 ON1. Additionally, the present disclosure also provides a viral vector comprising the fowl adenovirus, which has inserted an exogenous nucleotide sequence coding for at least one antigenic site of a disease of concern, as well as a method for obtaining said viral vector and an immunogenic composition comprising the same.
Claims12
A non-pathogenic fowl adenovirus serotype 4 viral vector comprising a nucleotide sequence with at least 95% sequence identity to SEQ ID NO:
- 2 and an exogenous nucleotide sequence coding for a polypeptide of interest.
Dependencies are inferred from the claim text.