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US 9,119,782 B2Granted
Drug delivery means
OwnerMary P. McCourtinventor
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OwnerMary P. McCourtinventor
Estimating the term…
The invention broadly comprises a chemical composition including a plurality of cholesteryl esters arranged to form a vesicle. In several embodiments, all of the plurality of cholesteryl esters have a same molecular length, which in some embodiments provides a vesicle having a generally smooth outer surface, while in other embodiments, a portion of the plurality of cholesteryl esters have different molecular lengths, which in some embodiments provides a vesicle having a generally irregular outer surface. In yet further embodiments, a shape of the vesicle is selected from the group consisting of spherical, oval, disc-like, tubular and polyhedral shapes, and in yet other embodiments, a wall of the vesicle is selected from the group consisting of a monolayer and a bilayer. In still further embodiments, the chemical composition further includes a polyethylene glycol coat of mixed polymer size. In some embodiments, the plurality of cholesteryl esters include at least two different cholesteryl esters, and in some of these embodiments, the at least two different cholesteryl esters are selected from the group consisting of: cholesteryl myristate, cholesteryl laurate, cholesteryl dodeconate, cholesteryl palmitate, cholesteryl arachidonate, cholesteryl behenate, cholesteryl linoleate, cholesteryl linolenate, cholesteryl oleate and cholesteryl stearate.
A chemical composition comprising a population of cholestosome vesicles, each vesicle comprising a hollow aqueous capable of being loaded with a chemical compound and an exterior layer enclosing said hollow compartment consisting essentially of a plurality of non-ionic cholesteryl fatty acid ester molecules selected from the group consisting of cholesteryl myristate, cholesteryl laurate, and mixtures thereof wherein said vesicle ranges in diameter from 1 nm to 1 micron.
A method of delivering a drug to cells comprising the steps of:
A method of manufacturing a plurality of cholestosome vesicles comprising the steps of:
A drug delivery system comprising a population of cholestosome vesicles each of which vesicles comprises a hollow compartment loaded with a drug manufactured by the steps comprising:
Dependencies are inferred from the claim text.