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US 9,115,163 B2Granted
DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
AssigneeThe Trustees of Columbia University in the City of New York
InventorsJingyue Ju, Dae H. Kim, Jia Guo, Qinglin Meng, Zengmin Li, Huanyan Cao
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Abstract
This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.
Claims3
A compound having the structure:
- wherein R′ is a cleavable chemical group;
- and wherein the base may have a detectable marker cleavably linked to it.
Dependencies are inferred from the claim text.