US 9,114,118 B2 · Compounds and compositions for the treatment of cancer

Abstract

New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

Claims19

Dependent claims

A method for treating cancer, wherein said method comprises administering to a subject in need of such treatment, a compound represented by Formula IC, or a pharmaceutically acceptable salt thereof:

wherein
n is 2, 3, 4, 5, or 6;
R is —C(O)—, —OC(O)—, —CH(OH)—, NH, NC1-C3 alkyl, O, S, or CH2;
A is (CH2)m,C(O)OH, W(CH2)mC(O)OH, or YCH(C(O)OH)(CH2)pCH3 when B is H;
B is (CH2)mC(O)OH, W(CH2)mC(O)OH or YCH(C(O)OH)(CH2)pCH3 when A is H;
or
A and B are covalently bonded to form a 5-, 6-, or 7-membered cycloalkyl substituted with a C(O)OH group;
W is O, S, or NH;
Y is O, S, NH or CH2;
m is 0, 1, or 2;
and
p is 1, 2, 3, 4, 5, 6, or 7.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/882,355Filed 26 Oct 2011 · us provisional application

Priority

27 Oct 2010

Published

US 2013/0217645 A122 Aug 2013

Granted

25 Aug 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification18 codes

A61K 31/192
Carboxylic acids, e.g. valproic acid: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/196
Having an amino group: the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/22
Of carboxylic acids: of acyclic acids, e.g. pravastatin
A61K 31/513
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: having oxo groups directly attached to the heterocyclic ring, e.g. cytosine

Compounds and compositions for the treatment of cancer

Life of this patent

Compounds and compositions for the treatment of cancer

Life of this patent

Abstract

Claims19