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US 9,114,101 B2Granted
P16INK4A derived peptides for prophylaxis and therapy of HPV-associated tumors and other P16INK4A expressing tumors
AssigneeRuprecht-Karls-Universitaet Heidelberg
InventorsMatthias Kloor, Miriam Reuschenbach, Magnus Von Knebel-Doeberitz
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Abstract
Described are particular fragments of the cyclin-dependent kinase inhibitor p16 capable of increasing IFN-γ secretion of T cells or inducing proliferation of T cells and the use of said fragments for immunizing an individual against HPV-associated or other p16INK4a expressing carcinomas, preferably advanced carcinomas.
Claims4
A fragment of the cyclin-dependent kinase inhibitor p16INK4 capable of inducing an immune response against p16INK4a, consisting of
- (a) any one of the following amino acid sequences:
- (SEQ ID NO:
- 3)
- (1) LPNAPNSYGRRPIQVMMMGSARVAELL;
- (SEQ ID NO:
- 4)
- (2) VMMMGSARVAELLLLHGAEPNCADPATLTR;
- (SEQ ID NO:
- 5)
- (3) ADPATLTRPVHDAAREGFLDTLVVLHRAGARL;
- or
- (b) a combination of fragments of (a).
9 more elements
Dependencies are inferred from the claim text.