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AssigneesThe Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
InventorsDavid B Weiner, Bernadette Ferraro, Jian Yan, Patricia A Brown, Rodney A Bowling, Douglas R Kern, Mathura P Ramanathan, Niranjan Y Sardesai, Karuppiah Muthumani
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Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
A pharmaceutical composition comprising a nucleic acid molecule comprising a nucleic acid sequence that encodes a protein selected from the group consisting of:
A pharmaceutical composition comprising a molecule comprising a nucleic acid sequence that encodes a protein comprising SEQ ID NO:
Dependencies are inferred from the claim text.