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US 9,108,927 B2Granted
Salts of an epidermal growth factor receptor kinase inhibitor
AssigneeCelgene Avilomics Research, Inc.
InventorsMei Lai, Steven Richard Witowski, Richland Wayne Tester, Kwangho Lee
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Abstract
The present invention provides a salt form and compositions thereof, which are useful as an inhibitor of EGFR kinases and which exhibits desirable characteristics for the same.
Claims20
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form I hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 17.39, about 19.45, about 21.41, about 23.56 and about 27.45 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form III hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 6.79, about 13.36, about 19.93, about 20.89, about 21.90, about 22.70, about 22.91 and about 26.34 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form IV hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 6.45, about 12.96, about 19.38, about 19.79, about 21.37 and about 21.58 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form V hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 6.17, about 6.99, about 12.50, about 14.14, about 17.72 and about 23.12 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form VI hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 8.38, about 9.38, about 18.93, and about 21.58 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form VII hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 15.91, about 19.10, about 19.53, about 20.24, about 22.64 and about 25.58 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 1;
- and
- X is hydrobromic acid;
- wherein the compound is a Form VIII hydrobromic acid salt characterized by one or more peaks in a powder X-ray diffraction pattern selected from those at about 8.79, about 11.13, about 19.97, about 21.31, about 21.56, about 25.30 and about 26.65 degrees 2-theta.
2 more elements
Compound 2:
- wherein:
- n is 2;
- and
- X is benzenesulfonic acid;
- wherein the compound is a hydrate having one or more peaks in a powder X-ray diffraction pattern selected from those at about 10.68, about 16.10, about 18.44 and about 22.36 degrees 2-theta.
2 more elements
Dependencies are inferred from the claim text.