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US 9,107,948 B2Granted
Compounds for diagnosing diseases associated with the expression of MUC5AC
AssigneeGuerbet
InventorsSébastien Ballet, Walter Gonzalez, Yannick Rossez
Life of this patent
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Abstract
The application relates to a compound of general formula (I) below: Signal-Linker-Peptide (I) and to the uses thereof for medical imaging or diagnosis or the preparation of a composition for diagnosis of an MUC5AC pathological condition.
Claims20
A compound and the pharmaceutically acceptable salts thereof, of the formula (I) Signal-Peptide or (II) Signal-Linker-Peptide, wherein:
- Signal is a signal entity;
- Linker is a chemical linking component;
- and
- Peptide is a peptide consisting of a mucin 5A (MUC5AC)-targeting peptide,
- wherein the MUC5AC-targeting peptide is selected from the group consisting of:
- a) X1-X2-X3-X4-X5-X6-X7-X8-X9 (SEQ ID No:
- 1), wherein:
- X1 is absent or cysteine or methionine,
- X2 is hydroxyproline or proline,
- X3 is threonine or serine,
- X4 is isoleucine, leucine or valine,
- X5 is tyrosine, phenylalanine or tryptophan,
- X6 is hydroxyproline or proline,
- X7 is isoleucine, leucine or valine
- X8 is isoleucine, leucine or valine
- X9 is absent or cysteine or methionine;
- b) X10-X11-X12-X13-X14-X15-X16-X17-X18 (SEQ ID No:
- 4), wherein:
- X10 is absent or cysteine or methionine,
- X11 is isoleucine, leucine, valine or alanine,
- X12 is threonine or serine,
- X13 is isoleucine, leucine or valine,
- X14 is hydroxyproline or proline,
- X15 is hydroxyproline or proline,
- X16 is isoleucine, leucine or valine,
- X17 is isoleucine, leucine or valine,
- X18 is absent or cysteine or methionine;
- and
- c) CALIPPLLC (SEQ ID No:
- 5).
27 more elements
A compound and the pharmaceutically acceptable salts thereof, the compound comprising the structure:
Dependencies are inferred from the claim text.