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US 9,107,924 B2Granted
Inhibitors of Bruton'S tyrosine kinase for the treatment of solid tumors
AssigneePharmacyclics, Inc.
InventorsJoseph J. Buggy, Laurence Elias
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Abstract
Described herein are irreversible Btk inhibitor compounds, and methods for using such irreversible inhibitors in the treatment of diseases and disorders characterized by the presence or development of solid tumors.
Claims3
A method for treating HER2 amplified breast cancer in an individual in need thereof comprising administering to an individual in need thereof a composition comprising a therapeutically-effective amount of a (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) having the structure:
Dependencies are inferred from the claim text.