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US 9,102,705 B2Granted
Peptide aptamers that bind to the rep proteins of ssDNA viruses
AssigneeNorth Carolina State University
InventorsLinda Hanley-Bowdoin, Luisa Lopez-Ochoa
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Abstract
Polypeptides and fusion proteins that bind to eukaryotic viruses, in particular, eukaryotic single-stranded DNA (ssDNA) viruses are provided. The polypeptides and fusion proteins bind to the replication initiation proteins (Rep) of ssDNA viruses and optionally inhibit viral replication and/or viral infection. The virus can be a plant pathogen or animal pathogen. Consensus sequences used to identify polypeptides that bind to eukaryotic viruses are also provided.
Claims26
A polypeptide comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:38;
- (b) a fragment of the amino acid sequence of SEQ ID NO:38, wherein the fragment comprises MHXXXXXG;
- and wherein the fragment binds to a viral replication (Rep) protein;
- and
- (c) an amino acid sequence having at least 95% sequence identity to the amino acid sequence of (a) or (b) and binds to a viral Rep protein selected from the group consisting of a geminivirus Rep protein, a nanovirus Rep protein, a circovirus Rep protein and combinations thereof;
- wherein X represents any amino acid.
3 more elements
Dependencies are inferred from the claim text.