Fatty acid amide hydrolase inhibitors

A medicament comprising a physiologically acceptable excipient and a therapeutically effective amount of a compound of formula R—X—Y, or any pharmaceutically acceptable salt thereof including all stereoisomers, the compound being in isolated and purified form, wherein:

• Y is selected from the following structures:
• Y2 is selected from -aryl-alkyl-Y14, -heteroaryl, -heteroaryl-alkyl, -heteroaryl-alkyl-Y14, -cycloalkyl, -heterocyclic, —C1-5-alkyl-Y14, -aryl-Y14, -heteroaryl-Y14;
• Y3 and Y4 are each F;
• Y14 is selected from —OH, SH, —N3, —NCS, —CONH2, —SO2NH2, —COOH, —COOMe, —NO2, —SO3H, —P(O )(OH)2;
• X is selected from —(CH2)n— and —(CH2)j-A-(CH2)k—;
• A is selected from O and NH;
• n is an integer from 0 to about 15;
• j is an integer from 0 to about 10;
• k is an integer from 0 to about 10;
• R is selected from the following structures:
• wherein:
• W3 is selected from CH and N if W3 is not bonded to X or R1 or R2, or W3 is C if W3 is bonded to X or R1 or R2, and if W3 is N then it can occupy any position selected from 1, 2, 3, 4, 5 and 6 in I 8;
• 2, 3, 4 and 5 in I 9;
• 1, 2, 3 and 4 in I 10;
• 2 and 3 in I11, I 12;
• W4 is selected from CH and N if W4 is not bonded to X or R1 or R2, or W4 is C if W4 is bonded to X or R1 or R2, and if W4 is N then it can occupy any position selected from 5, 6, 7 and 8 in I 10;
• 4, 5, 6 and 7 in I 11, I 12;
• W5 is selected from CH and N if W5 is not bonded to X or R4 or R5, or W5 is C if W5 is bonded to X or R4 or R5and if W5 is N then it can occupy any position selected from 1, 2, 3, 4, and 5 in I 16;
• W6 is selected from CH and N if W6 is not bonded to R6 or R7 or R8 or R9, or W6 is C if W6 is bonded to R6 or R7 or R8 or R9, and if W6 is N then it can occupy any position selected from 7, 8, 9, 10, and 11 in I 16;
• Q3 is selected from CH2, O, S and NH if Q3 is not bonded to X or R1 or R2, or Q3 is selected from CH and N if Q3 is bonded to X or R1 or R2;
• R1 and R2 are each independently selected from —H, —F, —Cl, —Br, —I, —OH, —SH, —NH2, —CN, —N3, —NCS, —CONH2, —SO2NH2, —COOH, —NO2, —CHO, —CF3, —SO3H, —O—P(O )(OH)2, -alkyl-R3, -aryl-R3, -heteroaryl-R3, -Z-al kyl-R3, -Z-aryl-R3, -Z-heteroaryl-R3, -Z-alkyl-aryl-R3, -Z-alkyl-heteroaryl-R3, —N(alkyl-R3)2, —C(O )N(alkyl-R3)2 and —SO2N(alkyl-R3)2;
• Z is selected from —O, —S, —NH;
• R3 is selected from —H, —F, —Cl, —Br, —I, -Me, -Et, —OH, —OAc, —SH, —NH2, —CN, —N3, —NCS, —CONH2, —SO2NH2, —COOH, —NO2, —CHO, —CF3;
• R4, R5, R6, R7, R8 and R9 are each independently selected from —H, —F, —Cl, —Br, —I, —OH, —OMe, -OEt, —OCH2OCH3, —OAc, —SH, —SMe, —SEt, —NH2, —CN, —N3, —NCS, —CONH2, —SO2NH2, —COOH, —NO2, —CHO, —CF3, -alkyl, -alkyl-R3.