Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
AssigneeSemprus Biosciences Corp.
InventorsJun Li, Zheng Zhang, Chad C. Huval, Michael A. Bouchard, Arthur J. Coury, Christopher R. Loose
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Abstract
A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
Claims25
An article of manufacture comprising a polymeric substrate having a surface and a grafted polymer layer on the substrate surface, the grafted polymer layer having a global average dry thickness of at least about 500 nanometers, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in a composition containing 70 μg/ml fibrinogen derived from human plasma and 1.4 μg/ml 1-125 radiolabeled fibrinogen and a water contact angle of less than 40 degrees.
Dependencies are inferred from the claim text.