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US 9,090,549 B2Granted
1,4-naphthoquinones derivatives and therapeutic use thereof
AssigneesCentre National de la Recherche Scientifique (CNRS), Reprecht-Karls-Universitat Heidelberg
InventorsElisabeth Davioud-Charvet, Tobias Muller, Holger Bauer, R. Heiner Schirmer
Life of this patent
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Abstract
1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
Claims10
A compound of formula (I)
- wherein -A is
- R6, which may be in position 5, 6, 7, or 8 of the phenyl ring of the naphthoquinone, represents a hydrogen atom, a halogen atom, a hydroxy group, a linear or branched (C1-C4)alkyl group, a di- or tri-fluoromethyl group, a trifluoromethoxy group, or a pentafluorosulfanyl group,
- n is an integer between 0 and 4, and
- R7 represents a methyl group;
- X represents —C(O)—or —CHY—, with Y being a hydrogen atom, or a hydroxy group;
- and
- R1, R2, R3, R4 and R5 each independently represent:
- a hydrogen atom,
- a halogen atom selected from the group consisting of Br, CI, and F,
- a hydroxy group,
- a methyl or t-butyl group,
- a di- or trifluoromethyl group,
- a methoxy group,
- a trifluoromethoxy group,
- —NH2,
- —NO2,
- —CN,
- —CONH(CH2)2CN
- -NHBoc,
- the group
- and
- a phenyl group substituted in the para position by a t-butyl group, —NO2, —N(CH3)2, or —NHC(CH3)3,
- or a pharmaceutically acceptable salt of said compound,
- with the proviso that said compound is not
21 more elements
Dependencies are inferred from the claim text.