A variable format offset printing machine having a central impression cylinder, said printing machine comprising said central impression cylinder (1) on which a web printable substrate (B) is supported and a plurality of printing stations arranged around the central impression cylinder (1), each of said printing stations comprising a blanket cylinder (2) of variable diameter, a plate cylinder (3) of variable diameter, and an offset inking unit (4), said blanket cylinder (2), plate cylinder (3) and offset inking unit (4) being movable between respective withdraw positions and respective multiple working positions for different diameters of the blanket and plate cylinders (2, 3), characterized in that in at least one of said printing stations:
- the axis of the blanket cylinder (2) and the axis of the plate cylinder (3) are comprised in a first plane (P1) inclined with respect to a horizontal plane, wherein said first plane (P1) does not comprise the axis of the central impression cylinder (1) at several of said multiple working positions for different diameters of the blanket and plate cylinders (2, 3);
- the axis of the blanket cylinder (2) and the axis of the plate cylinder (3) are movable in respective first and second horizontal planes (Hp1, Hp2);
- and
- said first plane (P1) forms an angle (A) ranging from 0° to 20° in absolute value with a second plane (P2) comprising the axis of the central impression cylinder (1) and the axis of the blanket cylinder (2) at any of said multiple working positions for different diameters of the blanket and plate cylinders (2, 3).