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US 9,079,940 B2Granted
Light-sensitive ion-passing molecules
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKarl Deisseroth, Feng Zhang, Viviana Gradinaru
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Abstract
Disclosed are polynucleotides and methods for expressing light activated proteins in animal cells and altering an action potential of the cells by optical stimulation. The disclosure also provides animal cells and non-human animals comprising cells expressing the light-activated proteins.
Claims14
An animal cell comprising a light-activated protein expressed on the cell membrane, wherein the protein comprises, in order from amino terminus (N-terminus) to carboxyl terminus (C-terminus):
- a) a core amino acid sequence at least 95% identical to the sequence shown in SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, or SEQ ID NO:4;
- b) an endoplasmic reticulum (ER) export signal;
- and
- c) a membrane trafficking signal.
1 more element
Dependencies are inferred from the claim text.