Cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides for reducing and/or eliminating facial wrinkles
AssigneeLipotec, S.A.
InventorsAntonio Vincente Ferrer Montiel, Juan Cebrián Puche, Arturo Puig Montiel
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Abstract
A cosmetic or dermopharmaceutical composition comprising enkephalin-derived peptides of general formula (I) for reducing and/or eliminating facial wrinkles is disclosed. The cosmetic or dermopharmaceutical composition can be applied to the skin, preferably skin of the face, to reduce and/or eliminate facial wrinkles, such facial expression wrinkles. Use of the peptide of general formula (I) in the preparation of a cosmetic or dermopharmaceutical composition for reducing and/or eliminating facial wrinkles is also disclosed.
Claims31
A method of treating facial wrinkles, comprising administering topically, intradermally or subcutaneously, a cosmetic or dermopharmaceutical composition comprising:
- a cosmetically or dermopharmaceutically effective amount of at least one peptide of general formula (I):
- or the cosmetically or dermopharmaceutically acceptable salts thereof, wherein:
- X is D-alanyl or D-seryl and Y is selected from the group consisting of natural amino acids in their L- or D-form and non-encoded amino acids,
- R1 is selected from the group consisting of H and alkyl, aryl, aralkyl, and acyl groups, and
- R2 is selected from the group consisting of amino, hydroxy, and thiol, all of them substituted or non-substituted with aliphatic or cyclic groups;
- and
- at least a cosmetically or dermopharmaceutically acceptable excipient or adjuvant;
- to the face of a subject to reduce facial wrinkles.
A method of treating facial wrinkles, comprising administering a cosmetically or dermopharmaceutically effective amount of at least one peptide of general formula (I):
- or the cosmetically or dermopharmaceutically acceptable salts thereof, wherein:
- X is D-alanyl or D-seryl and Y is selected from the group consisting of natural amino acids in their L- or D-form and non-encoded amino acids,
- R1 is selected from the group consisting of H and alkyl, aryl, aralkyl and acyl groups, and
- R2 is selected from the group consisting of amino, hydroxy and thiol, all of them substituted or non-substituted with aliphatic or cyclic groups;
- to the face of a subject to reduce facial wrinkles.
A cosmetic or dermopharmaceutical composition comprising:
- a cosmetically or dermopharmaceutically effective amount of at least one peptide of general formula:
- or the cosmetically or dermopharmaceutically acceptable salts thereof, wherein:
- X is D-alanyl or D-seryl and Y is selected from the group consisting of natural amino acids in their L- or D-form and non-encoded amino acids,
- R1 is selected from the group consisting of H and alkyl, aryl, aralkyl, and acyl groups, and
- R2 is selected from the group consisting of amino, hydroxy, and thiol, all of them substituted or non-substituted with aliphatic or cyclic groups;
- and
- a peptide containing at least one amino acid sequence derived from the amino acid sequence of the protein SNAP-25 defined by SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.