Method for data reduction and calibration of an OCT-based physiological monitor

Non-transitory computer-readable storage having stored thereon instructions that, when executed, direct a computing system to perform operations comprising:

• computing intensity differences between at least two OCT scans of biological tissue to generate an intensity difference plot;
• selecting, based portions of on the intensity difference plot having large changes in intensity, corresponding portions of the at least two OCT scans correlating with at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans;
• generating calibration data for an OCT device using the selected portions of the OCT scans;
• using the calibration data to calibrate subsequent OCT scans;
• and
• estimating blood analyte concentrations from the subsequent OCT scans.

An apparatus for estimating blood analyte concentrations using an optical coherence tomography (OCT) device, the apparatus comprising:

• a processor configured to:
• select at least two OCT scans from a plurality of OCT scans based in part on at least two blood analyte measurements, the at least two blood analyte measurements obtained independently from the at least two OCT scans;
• compute intensity differences between the at least two OCT scans of biological tissue;
• select based on portions of the computed intensity differences having large changes in intensity, corresponding portions of each of the OCT scans;
• generate calibration data for an OCT device based in part on the selected portions of the at least two OCT scans;
• use the calibration data to calibrate subsequent OCT scans;
• and
• estimate blood analyte concentrations from the subsequent OCT scans.

A method of estimating blood analyte concentrations using an optical coherence tomography (OCT) device, the method comprising:

• identifying at least one discontinuity in data associated with OCT scans of biological tissue;
• selecting, based on the at least one discontinuity, portions of each of the OCT scans correlating with blood analyte measurements obtained independently from the OCT scans;
• determining, using a processor, calibration data for an OCT device using the selected portions of the OCT scans;
• using the calibration data to calibrate subsequent OCT scans;
• and
• estimating blood analyte concentrations from the subsequent OCT scans.