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US 9,074,237 B2Granted
Method for diagnosing Francisella tularensis infection
AssigneeStc.Unm
InventorsGraham Timmins, Terry Wu, Seong Won Choi
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Abstract
The present invention is directed to the use of isotopically labeled citrulline for gnosing the presence or absence of a bacterial infection in the lungs of a patient.
Claims17
A method for diagnosing a presence or absence of a citrulline ureidase positive bacterial infection in the lungs of a patient comprising:
- administering a diagnostically effective amount of an isotopically-labeled citrulline, or a pharmaceutically acceptable salt thereof, to the lungs of the patient;
- collecting one or more breath, urine, whole blood, plasma, or serum samples from the patient;
- and
- analyzing the one or more samples to determine the amount of isotopically labeled carbon dioxide, isotopically labeled ammonia, or a mixture thereof in said samples;
- said amount indicating the presence or absence of the bacterial infection.
2 more elements
Dependencies are inferred from the claim text.