Methods and intermediates for preparing macrolactams
AssigneeMerck Sharp & Dohme Corp.
InventorsNobuyoshi Yasuda, Jeffrey T. Kuethe, Guy Humphrey, Gregory L. Beutner, Yong-Li Zhong, Edward Cleator, Carl Baxter
Life of this patent
Estimating the term…
Abstract
A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)RA, or C(O)NHCH(X)COOH; provided that X is a C2-C6 alkyl, or a C3-C8 cycloalkyl and RA is a C1-6 alkyl or aryl; These compounds are used to make Compound A
Claims12
A compound selected from the group consisting of:
- wherein R is either H, acetyl, or C(O)NHCH(X)COOH, and X is a C2-C6 alkyl, or a C3-C8 cycloalkyl,
- and salts thereof, wherein Y is a protecting group or H and wherein PG is a protecting group.
A method of making Compound 6, comprising the step of reacting
- (Compound 5) with an acetylating agent to produce
- (Compound 6).
A method of making a compound of Formula I
- wherein R is C(O)NHCH(X)COOH, X is a C2-C6 alkyl, or a C3-C8 cycloalkyl;
- or a salt thereof;
- comprising the step of reacting
- (Compound 7) with
- to produce Compound 8.
A method of producing Compound 13, comprising the step of reacting Compound 11 with Compound 12 to produce Compound 13:
- wherein PG is a protecting group.
A method of producing Compound 14 comprising the step of reacting Compound 13 with Compound 8 to produce Compound 14 or salts thereof:
- wherein PG is a protecting group.
Dependencies are inferred from the claim text.