Methods of treating obesity by inhibiting nicotinamide N-methyl transferase (NNMT)
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsBarbara B. Kahn, Qin Yang, Daniel Kraus
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Abstract
The present invention, in various embodiments, relates to methods of inhibiting NNMT production or activity in a cell, and methods of treating or preventing obesity or a related metabolic condition in a subject in need thereof, comprising administering a nicotinamide N-methyltransferase (NNMT) antagonist. The invention further provides methods of identifying NNMT antagonists useful for treating obesity and related metabolic disorders.
Claims34
A method of inhibiting the expression or activity of a nicotinamide N-methyltransferase (NNMT) protein in a cell, comprising providing the cell with an effective amount of at least one NNMT antagonist, wherein the NNMT antagonist is a nucleic acid that inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof, and wherein the cell is an adipocyte or a hepatocyte.
A method of treating or preventing obesity in a subject in need thereof, comprising administering to the subject an effective amount of a nicotinamide N-methyltransferase (NNMT) antagonist, wherein the NNMT antagonist inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof.
A method of treating or preventing a metabolic disorder in a subject in need thereof, comprising administering to the subject an effective amount of a nicotinamide N-methyltransferase (NNMT) antagonist, wherein the NNMT antagonist inhibits production of NNMT protein, one or more activities of an NNMT protein, or a combination thereof.
Dependencies are inferred from the claim text.