Automatic segmentation and characterization of cellular motion
AssigneeGeneral Electric Company
InventorsXiaofeng Liu, Dirk Ryan Padfield
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Abstract
The present techniques provide for the evaluation of cellular motion and/or cellular properties based on an analysis of motion for cluster of cells. In an exemplary technique, images of cells are acquired and the image is segmented into clusters. Motion data for each respective cluster is derived from the segmented data. The properties of each cluster can be used to evaluate cellular properties and/or cellular motion properties.
Claims20
A method for evaluating cellular motion and/or properties, comprising:
- receiving image data corresponding to images of a plurality of cells;
- segmenting the image data into a plurality of clusters based on a motion pattern associated with the plurality of cells;
- extracting a motion signal from the segmented image data of each respective cluster of the plurality of clusters, wherein the motion signal comprises a periodic motion associated with a rhythm frequency of each individual cluster;
- and
- evaluating at least one of cellular motion properties or cellular properties based on the motion signal from each respective cluster.
A computer program provided on one or more tangible computer-readable media, the computer program comprising:
- a memory storing executable instructions configured to:
- receive image data corresponding to images acquired over time of a plurality of cells;
- segment the image data into a plurality of clusters based on a motion pattern associated with the plurality of cells, wherein each individual cluster represents only a portion of the plurality of cells and wherein the image data is not separated into motion components before being segmented into the plurality of clusters;
- extract a motion signal from each respective cluster of the plurality of clusters, wherein the motion signal comprises a periodic motion associated with a rhythm frequency of each individual cluster;
- evaluate at least one of cellular motion properties or cellular properties based on the motion signal from each respective cluster;
- and
- generate an output indicative of the cellular motion properties of the plurality of clusters.
An image analysis system, comprising:
- an imager configured to optically analyze a plurality of cells;
- data acquisition circuitry configured to acquire images of the plurality of cells via the imager;
- and
- data processing circuitry configured to:
- segment image data from the images of the plurality of cells into a plurality of clusters based on a motion pattern associated with the plurality of cells, extract a motion signal from the segmented image data of each individual cluster, wherein the motion signal comprises a periodic motion associated with a rhythm frequency of each individual cluster, and evaluate at least one of cellular motion properties or cellular properties based on the motion signal of each individual cluster.
Dependencies are inferred from the claim text.