Compositions and methods of detecting TIABs
AssigneeTransmedi SA
InventorsBernard Bihain, Virginie Ogier, Marie Brulliard
Life of this patent
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Abstract
The present invention relates to novel methods and products for assessing the physiological status of a subject. More particularly, the invention relates to methods of assessing the presence, risk or stage of a cancer in a subject by measuring the levels of antibodies against particular aberrant protein domains in a sample from the subject, or the presence or number of immune cells hearing TCR specific for such aberrant protein domains. The invention is also suitable to assess the responsiveness of a subject to a treatment, as well as to screen candidate drugs and design novel therapies. The invention may be used in any mammalian subject, particularly in human subjects.
Claims13
A method for detecting the presence of a lung cancer in a subject, the method comprising contacting in vitro:
- (i) a sample from the subject, said sample being previously treated by heating between 36° C. and 60° C. to activate a Transcription Infidelity Antibody (TIAB), with
- (ii) a polypeptide comprising a sequence selected from the group consisting of SEQ ID NOs:
- 3, 4, 7, 80, 581, 847, 1276, 1396, 1413, 1457, 1499, 1757, 1769, 1770 and 1810,
- wherein the formation of a complex between said polypeptide and said TIAB in said sample is an indication of the presence of a lung cancer, said TIAB being an IgG antibody.
A method for detecting the presence of a breast cancer in a subject, the method comprising contacting in vitro:
- (i) a sample from the subject, said sample being previously treated by heating between 36° C. and 60° C. to activate a Transcription Infidelity Antibody (TIAB), with
- (ii) a polypeptide comprising a sequence selected from the group consisting of SEQ ID NOs:
- 6, 11, 581, 847, 911, 1396, 1413, 1451, 1457, 1499, 1699 and 1770,
- wherein the formation of a complex between said polypeptide and said TIAB in said sample is an indication of the presence of breast cancer, said TIAB being an IgG.
A method for detecting the presence of a lung cancer in a subject, the method comprising contacting in vitro:
- (i) a sample from the subject, said sample being previously treated by heating between 36° C. and 60° C. to activate a Transcription Infidelity Antibody (TIAB), with
- (ii) a polypeptide comprising amino acids 1-30 of SEQ ID NO:
- 80, amino acids 1-30 of SEQ ID NO:
- 581, amino acids 1-30 of SEQ ID NO:
- 847, amino acids 2-31 of SEQ ID NO:
- 1276, amino acids 1-30 of SEQ ID NO:
- 1396, amino acids 1-19 of SEQ ID NO:
- 1413, amino acids 1-30 of SEQ ID NO:
- 1457, amino acids 1-30 of SEQ ID NO:
- 1769, or amino acids 2-31 of SEQ ID NO:
- 1770, wherein the formation of a complex between said polypeptide and said TIAB in said sample is an indication of the presence of a lung cancer, said TIAB being an IgG antibody.
Dependencies are inferred from the claim text.