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US 9,068,986 B2Granted
Influenza B viruses having alterations in the hemagglutinin polypeptide
AssigneeMedImmune, LLC
InventorsHong Jin, Zhongying Chen
Life of this patent
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Abstract
The present invention encompasses methods of producing influenza B viruses in cell culture. The influenza B viruses may have desirable characteristics, such as enhanced replication in eggs and may be used, for example, in vaccines and in methods of treatment to protect against influenza B virus infection.
Claims11
A method of preparing influenza B virus comprising:
- (a) introducing a mutation in a hemagglutinin (HA) genome segment resulting in an amino acid substitution at position 141 to arginine, thereby generating a modified HA polypeptide;
- and
- (b) replicating an influenza B virus comprising the modified HA polypeptide under conditions whereby influenza B virus is produced, wherein the influenza B virus comprising the modified HA polypeptide replicates to a higher titer than an influenza B virus comprising an HA polypeptide that is unmodified at position 141.
Dependencies are inferred from the claim text.