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US 9,068,971 B2Granted
Methods for treating and/or limiting development of diabetes
AssigneeBioCrine AB
InventorsPer Olof Berggren, Shao-Nian Yang
Life of this patent
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Abstract
The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
Claims10
A method for identifying candidate compounds for limiting development of and/or treating diabetes, comprising
- a) contacting a first population of insulin secreting cells with an amount of ApoCIII effective to increase density and/or conductivity of Cav1 channels, in the presence of one or more test compounds;
- and
- b) identifying those positive test compounds that inhibit the ApoCIII-induced increase in density and/or conductivity of Cav1 channels and that inhibit SRBI expression or activity in the first population of insulin secreting cells compared to control, wherein the control comprises contacting a second population of insulin secreting cells with an amount of ApoCIII effective to increase density and/or conductivity of Cav1 channels, in the absence of test compounds;
- wherein the positive test compounds are candidate compounds for limiting development of and/or treating diabetes.
1 more element
Dependencies are inferred from the claim text.