Methods and compositions involving miRNA and miRNA inhibitor molecules
AssigneeAsuragen, Inc.
InventorsDavid Brown, Lance Ford, Angie Cheng, Rich Jarvis, Mike Byrom, Dmitriy Ovcharenko, Eric Devroe, Kevin Kelnar
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Abstract
The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
Claims33
A method comprising introducing into a cancer cell an effective amount of a synthetic miR-215 molecule comprising a miR-215 active strand and a separate passenger strand that is at least 60% complementary to the active strand.
Dependencies are inferred from the claim text.