Use of compounds for inducing differentiation of mesenchymal stem cells to chondrocytes
AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsKi Chul Hwang, Yang Soo Jang, Gyoon Hee Han
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Abstract
Use of a compound of Formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of Formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of Formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect.
Claims4
A method of inducing differentiation of mesenchymal stem cells to chondrocytes, comprising:
- incubating the mesenchymal stem cells in a medium comprising at least one compound selected from the group consisting of:
- 1) quinoline-8-sulfonic acid (4-hydroxy-phenyl)-amide;
- 2) quinoline-8-sulfonic acid (7-hydroxy-naphthalen-1-yl)-amide;
- 3) 2-hydroxy-5-(quinoline-8-sulfonylamino)-benzoic acid;
- 4) 5-(4-tert-butyl-benzenesulfonylamino)-2-hydroxy-benzoic acid;
- 5) biphenyl-4-sulfonic acid (5-hydroxy-naphthalen-1-yl)-amide;
- 6) N-(4-hydroxy-naphthalen-1-yl)-4-methyl-benzenesulfonamide;
- 7) naphthalene-2-sulfonic acid (4-hydroxyl-phenyl)-amide;
- 8) N-(5-hydroxyl-naphthalen-1-yl)-4-methyl-benzenesulfonamide;
- 9) N-(7-hydroxyl-naphthalen-1-yl)-4-methyl-benzenesulfonamide;
- 10) 4-tert-butyl-N-(3-hydroxyl-phenyl)-benzenesulfonamide;
- 11) 4-tert-butyl-N-(2-chloro-4-hydroxyl-phenyl)-benzenesulfonamide;
- 12) biphenyl-4-sulfonic acid (2-chloro-4-hydroxyl-phenyl)-amide;
- 13) naphthalene-2-sulfonic acid (2-chloro-4-hydroxyl-phenyl)-amide;
- 14) 4-tert-butyl-N-(2-fluoro-4-hydroxyl-phenyl)-benzenesulfonamide;
- 15) biphenyl-4-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide;
- 16) naphthalene-2-sulfonic acid (2-fluoro-4-hydroxyl-phenyl)-amide;
- 17) 4-tert-butyl-N-(3-fluoro-4-hydroxyl-phenyl)-benzenesulfonamide;
- 18) biphenyl-4-sulfonic acid (3-fluoro-4-hydroxyl-phenyl)-amide;
- 19) naphthalene-2-sulfonic acid (3-fluoro-4-hydroxyl-phenyl)-amide;
- 20) naphthalene-2-sulfonic acid (3-nitro-4-hydroxyl-phenyl)-amide;
- 21) 4-tert-butyl-N-[2-(3,4-dihydroxyl-phenyl)-ethyl]-benzenesulfonamide;
- 22) biphenyl-4-sulfonic acid [2-(3,4-dihydroxyl-phenyl)-ethyl]-amide;
- 23) naphthalene-2-sulfonic acid [2-(3,4-dihydroxyl-phenyl)-ethyl]-amide;
- 24) 4-tert-butyl-N-ethyl-N-(5-hydroxyl-2-methyl-phenyl)-benzenesulfonamide;
- 25) naphthalene-2-sulfonic acid ethyl-(5-hydroxyl-2-methyl-phenyl)-amide;
- 26) 4-tert-butyl-N-[4-(2-hydroxyl-ethyl)-cyclohexyl]-benzenesulfonamide;
- 27) biphenyl-4-sulfonic acid [4-(2-hydroxyl-ethyl)-cyclohexyl]-amide;
- and
- 28) naphthalene-2-sulfonic acid [4-(2-hydroxyl-ethyl)-cyclohexyl]-amide.
Dependencies are inferred from the claim text.