Therapeutic applications of P53 isoforms in regenerative medicine, aging and cancer
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, University of Dundee, Masaryk Memorial Cancer Institute
InventorsCurtis C. Harris, Kaori Fujita, Izumi Horikawa, Borivoj Vojtesek, Jean-Christophe Bourdon, David P. Lane
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Abstract
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor protein. The methods and compositions of the invention find use in inhibiting cancer cell growth or in generating populations of cells for tissue regeneration through the modulation of cell senescence and proliferation.
Claims9
A method of extending the replicative lifespan of a cell that has a finite number of cell divisions by inhibiting cell senescence, the method comprising the step of contacting the cell with an agent that activates the function or expression of Δ133p53, thereby inhibiting cell senescence and extending the replicative lifespan of the cell, wherein the agent comprises a polynucleotide sequence encoding Δ133p53 or an expression cassette comprising a polynucleotide sequence encoding Δ133p53.
A method of extending the replicative lifespan of a cell that has an endogenous wild-type p53 gene by inhibiting cell senescence, the method comprising the step of contacting the cell with an agent that activates the function or expression of Δ133p53, thereby inhibiting cell senescence and extending the replicative lifespan of the cell, wherein the agent comprises a polynucleotide sequence encoding Δ133p53 or an expression cassette comprising a polynucleotide sequence encoding Δ133p53.
Dependencies are inferred from the claim text.