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US 9,068,021 B2Granted
Low-substituted hydroxypropylcellulose powder
AssigneeShin-Etsu Chemical Co., Ltd.
InventorsNaosuke Maruyama, Hiroshi Umezawa
Life of this patent
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Abstract
Provided is a low-substituted hydroxypropylcellulose powder having high compressibility, good flowability and excellent disintegration. The powder has an average particle size of 10 to 100 μm and a specific surface area measured by BET method of at least 1.0 m2/g.
Claims3
A low-substituted hydroxypropylcellulose powder having:
- a molar substitution number per anhydrous glucose unit of 0.05 to 1.0;
- an average particle size of 10 to 100 μm;
- a specific surface area measured by the BET method of at least 1.0 m2/g;
- an elastic recovery ratio of not greater than 7% when compressed at a compression pressure of 50 MPa;
- and a repose angle of not greater than 42°,
- wherein the elastic recovery ratio of the powder is calculated according to the following equation:
- Elastic
-
-
- recovery
-
-
- ratio
- =
- (
- tablet
-
-
- thickness
-
-
- after
-
-
- 30
-
-
- seconds
- -
- minimum
-
-
- tablet
-
-
- thickness
- )
- (
- minimum
-
-
-
- tablet
-
-
- thickness
- )
- ×
- 100
- wherein tablet thickness is determined for a tablet obtained by compression of the powder into a tablet with a weight of 480 mg and a compression force of 50 MPa using a flat shape with a flat contact face for a tablet diameter of 11.3 mm, wherein minimum tablet thickness is determined at its lowest point when the powder is compressed by an upper punch of a flat shape unit with a fixed lower punch, and tablet thickness after 30 seconds is the tablet thickness determined 30 seconds after the upper punch is removed.
47 more elements
Dependencies are inferred from the claim text.