Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
AssigneeHanall Biopharma Co., Ltd.
InventorsSung Wuk Kim, Sung Soo Jun, Seung Kook Park, Song Young Kim, Eun Sun Kim, Jae Kap Jeong, Ha Na Kim, Yeon Jung Song
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Abstract
The present invention relates to a modified human tumor necrosis factor receptor-1 polypeptide to be coupled to a tumor necrosis factor in vivo or ex vivo, or to a fragment thereof. The modified human tumor necrosis factor receptor-1 polypeptide or the fragment thereof according to the present invention exhibit improved resistance against in vivo protease activity, and thus exhibit improved bioavailability and an improved absorption rate.
Claims8
A modified human tumor necrosis factor receptor-1 polypeptide, comprising an amino acid sequence selected from the group consisting of:
- an amino acid sequence having one or more amino acid modifications selected from the group consisting of L150I, K161Q, K161N, D207N, L68V/K161Q, L68V/K161N and L68V/D207N in the amino acid sequence consisting of amino acid residues 41-211 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO:
- 1;
- an amino acid sequence having one or more amino acid modifications selected from the group consisting of L68V, R133Q, W136S, F141I and F141V in the amino acid sequence consisting of amino acid residues 41-166 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO:
- 1;
- and an amino acid sequence having one or more amino acid modifications selected from the group consisting of positions L68I, L68V, E85N, R106H, R128H, R133Q, Y135I, W136S, F141I and F141V in the amino acid sequence consisting of amino acid residues 41-148 of the amino acid sequence of a native human tumor necrosis factor receptor-I as set forth in SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.