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US 9,068,014 B2Granted
Colon and pancreas cancer peptidomimetics
AssigneePrecision Biologics, Inc.
InventorXue-Ping Wang
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Abstract
The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
Claims26
An isolated polypeptide comprising a polypeptide having at least 90% identity to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO:
- 1), wherein X1 is L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SX1PX2DX3FRYX4NX5K (SEQ ID NO:
- 2), wherein X1 is L;
- X2 is E or D;
- X3 is Y or W;
- X4 is T or I and X5 is Q or Y;
- SLPDDWFRYINY (SEQ ID NO:
- 5);
- YSHSSLPDDWFRYINYGGGS (SEQ ID NO:20);
- or SLPDDWFRYINYSLPDDWFRYINY (SEQ ID NO:24).
10 more elements
Dependencies are inferred from the claim text.