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US 9,068,011 B2Granted
Monoclonal antibodies against c-Met
AssigneeGenmab A/S
InventorsJoost J. Neijssen, Bart De Goeij, Edward Norbert Van Den Brink, Aran Frank Labrijn, Rene Hoet, Janine Schuurman, Paul Parren, Jan Van De Winkel
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Abstract
Isolated monoclonal antibodies which bind to human c-Met, the hepatocyte growth factor receptor, and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
Claims24
An isolated human monoclonal antibody which binds human c-Met and comprises:
- (i) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 34, 185 and 36 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 38, 39 and 206,
- (ii) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 191, 192 and 193 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 78, 79 and 208,
- (iii) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 194, 195 and 196 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 209, 210 and 104;
- (iv) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 197, 198 and 116 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 118, 119 and 211, or
- (v) a VH region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 199, 200 and 201 and a VL region comprising the CDR1, 2 and 3 sequences of SEQ ID NO:
- 126, 212 and 128.
12 more elements
An isolated human monoclonal antibody which binds human c-Met and comprises a heavy and light chain variable region, wherein:
- (a) the VH region comprises the sequence of SEQ ID NO:
- 33 and the VL region comprises the sequence of SEQ ID NO:
- 37,
- (b) the VH region comprises the sequence of SEQ ID NO:
- 65 and a VL region comprising the sequence of SEQ ID NO:
- 69,
- (c) the VH region comprises the sequence of SEQ ID NO:
- 73 and the VL region comprises the sequence of SEQ ID NO:
- 77,
- (d) the VH region comprises the sequence of SEQ ID NO:81 and the VL region comprises the sequence of SEQ ID NO:
- 85,
- (e) the VH region comprises the sequence of SEQ ID NO:89 and the VL region comprises the sequence of SEQ ID NO:
- 93,
- (f) the VH region comprises the sequence of SEQ ID NO:97 and the VL region comprises the sequence of SEQ ID NO:
- 101,
- (g) the VH region comprises the sequence of SEQ ID NO:
- 113 and the VL region comprises the sequence of SEQ ID NO:
- 117,
- (h) the VH region comprises the sequence of SEQ ID NO:
- 121 and the VL region comprises the sequence of SEQ ID NO:
- 125,
- (i) the VH region comprises the sequence of SEQ ID NO:
- 129 and the VL region comprises the sequence of SEQ ID NO:
- 133,
- (j) the VH region comprises the sequence of SEQ ID NO:
- 159 and the VL region comprises the sequence of SEQ ID NO:
- 160,
- (k) the VH region comprises the sequence of SEQ ID NO:
- 161 and the VL region comprises the sequence of SEQ ID NO:
- 162,
- (l) the VH region comprises the sequence of SEQ ID NO:
- 163 and the VL region comprises the sequence of SEQ ID NO:
- 164,
- (m) the VH region comprises the sequence of SEQ ID NO:
- 165 and the VL region comprises the sequence of SEQ ID NO:
- 166,
- (n) the VH region comprises the sequence of SEQ ID NO:
- 137 and the VL region comprises the sequence of SEQ ID NO:
- 138,
- (o) the VH region comprises the sequence of SEQ ID NO:
- 139 and the VL region comprises the sequence of SEQ ID NO:
- 140,
- (p) the VH region comprises the sequence of SEQ ID NO:
- 141 and the VL region comprises the sequence of SEQ ID NO:
- 142, or
- (q) the VH region comprises the sequence of SEQ ID NO:
- 143 and the VL region comprises the sequence of SEQ ID NO:
- 144.
45 more elements
Dependencies are inferred from the claim text.