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AssigneeRoche Glycart AG
InventorsEkkehard Mössner, Thomas U. Hofer, Ralf Jörg Hosse, Pablo Umaña
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The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies or variants thereof specific for cell surface or membrane bound human CEA. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
An antigen binding molecule (ABM) comprising a humanized, affinity-matured antigen binding domain as compared to the murine monoclonal antibody PR1A3, wherein said antigen binding domain specifically binds membrane-bound human carcinoembryonic antigen (CEA) and binds the same epitope as, or is capable of competing for binding with, the murine monoclonal antibody PR1A3, and, wherein said antigen binding domain comprises a heavy chain variable region comprising the complementarity determining regions (CDRs):
An isolated antibody that specifically binds to membrane-bound CEA with a monovalent KD of no more than about 100 nM, said antibody comprising the heavy chain variable region of SEQ ID NO:107 and the light chain variable region of SEQ ID NO:108, wherein said antibody has increased ADCC compared to the murine PR1A3 antibody.
An isolated anti-CEA antibody comprising a heavy chain variable region comprising:
Dependencies are inferred from the claim text.