Anti-P-selectin antibodies

An isolated antibody or binding fragment thereof which specifically binds to a conformational epitope of P-selectin, wherein the conformational epitope is within amino acid positions 1-35 of SEQ ID NO:1,

• wherein the antibody or binding fragment thereof comprises the ability to block the binding of P-selectin glycoprotein ligand-1 (PSGL-1) to P-selectin;
• and
• wherein the antibody or binding fragment thereof further comprises the ability to cause dissociation of a preformed P-selectin-PSGL-1 complex,
• wherein the amino acids in amino acid positions 4, 14, 17, 21, and 22 are H, I, K, N, and R, respectively,
• provided that the antibody or binding fragment thereof is not G1 antibody, the G1 antibody comprising variable light chains each individually having an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 45, 49, 51, 53, and 65, and further comprising variable heavy chains each individually having an amino acid sequence selected from the group consisting of SEQ ID NOs:
• 59, 63, and 67;
• further provided that the antibody or binding fragment thereof is not hSel001 antibody comprising variable light chains each individually having an amino acid sequence of SEQ ID NO:38 and variable heavy chains each individually having an amino acid sequence of SEQ ID NO:42;
• further provided that the antibody or binding fragment thereof is nota binding fragment of the G1 antibody;
• or a binding fragment of the hSe1001 antibody.