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US 9,067,993 B2Granted
Antibody neutralizers of human granulocyte macrophage colony stimulating factor
AssigneeAmgen Research (Munich) GmbH
InventorsTobias Raum, Julia Hepp, Eva Vieser, Silke Petsch, Steven Zeman, Andreas Wolf, Sandra Bruckmaier
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Abstract
The present invention relates to a human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF.
Claims20
A human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF, comprising in its light chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO:
- 16, a CDR2 comprising an amino acid sequence as set out in SEQ ID) NO:
- 17 and a CDR3comprising an amino acid sequence as set out in SEQ ID NO:
- 18;
- and comprising in its heavy chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO:
- 14, a CDR2 comprising an amino acid sequence as set out in SEQ ID NO:
- 15 and a CDR3 comprising an amino acid sequence as set out in any of SEQ ID NOs:
- 1-13 or 56.
4 more elements
An immunoglobulin G antibody which binds to human GM-CSF, comprising in its light chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO:
- 16, a CDR2 comprising an amino acid sequence as set out in SEQ ID NO:
- 17and a CDR3 comprising an amino acid sequence as set out in SEQ ID NO:
- 18;
- and
- comprising in its heavy chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO:
- 14, a CDR2 comprising an amino acid sequence as set out in SEQ ID NO:
- 15 and a CDR3 comprising an amino acid sequence as set out in SEQ ID NO:
- 2.
5 more elements
Dependencies are inferred from the claim text.