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AssigneeAlderbio Holdings LLC
InventorsLeon F. Garcia-Martinez, John Latham, Ethan W. Ojala, Corinne C. Akatsuka, Pei Fan, Jeffrey T. L. Smith, Benjamin H. Dutzar
Estimating the term…
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
A method of treating pain or eliciting an analgesic effect in an individual, comprising administering an effective amount of at least one anti-human NGF antibody or fragment thereof, wherein the anti-NGF antibody comprises the light chain complementarity determining region (CDR)1 of SEQ ID NO:15, the light chain CDR2 of SEQ ID NO:16, the light chain CDR3 of SEQ ID NO:17, the heavy chain CDR1 of SEQ ID NO:18, the heavy chain CDR2 of SEQ ID NO:19, and the heavy chain CDR3 of SEQ ID NO:20, or an antibody or antibody fragment that competes with any of the foregoing antibodies, and/or an antibody or antibody fragment that binds to the same or overlapping epitope as any of the foregoing antibodies.
Dependencies are inferred from the claim text.