S. aureus polypeptide and antibodies
AssigneeAbsynth Biologics Limited
InventorsSimon J. Foster, Jorge Garcia-Lara
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Abstract
The invention relates to antigenic polypeptides expressed by pathogenic microbes, vaccines comprising said polypeptides; therapeutic antibodies directed to said polypeptides and methods to manufacture said polypeptides, vaccines and antibodies.
Claims9
An isolated monoclonal, humanized or chimeric antibody, or an effective binding part thereof, which binds an isolated antigenic polypeptide encoded by an isolated nucleic acid consisting of SEQ ID NO:
- 6.
A method for preparing a hybridoma cell-line comprising the steps of:
- i) immunizing an immunocompetent mammal with a polypeptide consisting of an amino acid sequence of SEQ ID NO:
- 13;
- ii) fusing lymphocytes of the immunized immunocompetent mammal with myeloma cells to form hybridoma cells;
- iii) screening monoclonal antibodies produced by the hybridoma cells of step (ii) for binding activity to the polypeptide of i);
- iv) culturing the hybridoma cells to proliferate and/or to secrete said monoclonal antibody;
- and
- v) recovering the monoclonal antibody from the culture supernatant.
An isolated monoclonal, humanized or chimeric antibody, or an effective binding part thereof, which binds an isolated antigenic polypeptide consisting of SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.