US 9,067,972 B2 · Skin aging-inhibiting peptide

Abstract

The present invention provides a peptide and a composition which are suitable for oral ingestion, and which have a skin aging-inhibiting activity, a collagen-production promoting activity, an epidermal turnover promoting activity, and a cutaneous cell-proliferating effect. The present invention also provides a medicament and a functional food which have a skin aging-inhibiting activity, a collagen-production promoting activity, and a cutaneous cell-proliferation promoting activity. The present invention provides a composition including at least one peptide of Asn-lle-Pro-Pro-Leu, lle-Pro-Pro-Leu, lle-Pro-Pro, Pro-Val-Val-Val-Pro-Pro, Val-Pro-Pro-Phe, Val-Pro-Pro, Phe-Pro-Pro-Gln, and Leu-Pro-Pro-Thr.

Claims2

Dependent claims

A method of treating the symptoms of skin aging, comprising:

administering at least one peptide consisting of the following i) to vi) or a salt thereof to a subject with symptoms of skin aging to promote collagen production and/or epidermal cell proliferation:
i) Asn-Ile-Pro-Pro-Leu (SEQ ID NO:
3),
ii) Ile-Pro-Pro-Leu (SEQ ID NO:
2),
iii) Val-Pro-Pro-Phe (SEQ ID NO:
5),
iv) Pro-Val-Val-Val-Pro-Pro (SEQ ID NO:
6),
v) Phe-Pro-Pro-Gln (SEQ ID NO:
7), and
vi) Leu-Pro-Pro-Thr (SEQ ID NO:
10),
wherein the symptoms of skin aging are selected from the group consisting of wrinkles, spots and sagging of skin.

11 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/874,610Filed 2 Sep 2010 · continuation

Priority

JP 2008-31833415 Dec 2008

Published

US 2011/0092431 A121 Apr 2011

Granted

30 Jun 2015

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 5/101
And aliphatic: the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
A61P 17/00
Drugs for dermatological disorders
A61P 17/16
Drugs for dermatological disorders: emollients or protectives, e.g. against radiation
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00

Skin aging-inhibiting peptide

Life of this patent

Skin aging-inhibiting peptide

Life of this patent

Abstract

Claims2