N-acyldipeptide derivatives and their uses
OwnerRuey J. Yu, Eugene J. Van Scottinventors
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Abstract
N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject.
Claims3
A method of treating eczema, itch, pruritus, psoriasis, or dermatitis in a subject in need thereof, comprising topically administering to the skin of the subject a composition comprising a therapeutically effective amount of a dipeptide derivative having the following generic Formula (I):
- R1-AAB-AAC-R2 Formula (I)
- or an isomer or salt thereof, and optionally a pharmaceutically or cosmetically acceptable carrier, wherein R1 is an acyl radical having up to 9 carbon atoms;
- AAB is tyrosine and AAC is tyrosine, or AAB is valine and AAC is alanine;
- R2 is OR3, NHR4 or NHNHR5;
- R3 is H, an alkyl, aralkyl or aryl radical having up to 19 carbon atoms;
- and R4 or R5 is independently H, OH, an alkyl, aralkyl, or aryl radical having up to 19 carbon atoms.
Dependencies are inferred from the claim text.