N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists

A compound of Formula Ia or a stereoisomer or pharmaceutically acceptable salt thereof:

• wherein:
• R is CH3;
• R1 is independently selected from:
• H, C1-8 alkyl, and C3-8 cycloalkyl;
• R2 is selected from:
• H, C1-8 alkyl-C3-8 cycloalkyl, C3-8cycloalkyl-C1-8 alkylene-, C1-8 alkoxy-C1-8 alkylene-, 5-10 membered heterocyclyl, 5-10 membered heterocyclyl-C1-8 alkylene-, 5-10 membered heteroaryl, 5-10 membered heteroaryl-C1-8 alkylene-, aryl, and aryl-C1-8 alkylene-;
• ring A is a phenyl ring or a 5-6 membered heteroaryl attached via the carbon atom shown and having 1-3 ring heteroatoms selected from O, N, and S(O)p;
• ring A is optionally substituted with 1-3 R3 groups;
• R3 is independently selected from:
• C1-8 alkyl, F, Cl, Br, I, —CN, ORa, SRa, NRaRb, CF3, OCF3, CORa, CO2Ra, C(O)NRaRb, OC(O)Ra, OCO2Ra, OC(O)NRaRb, NRbCORa, NRbCO2Ra, NRbC(O)NRaRb, S(O)pNRaRb, C3-10cycloalkyl, C3-10cycloalkyl-C1-8alkylene-, 5-10 membered heterocyclyl, 5-10 membered heterocyclyl-C1-8alkylene-, aryloxy, aryl, aryl-, -C1-8alkylene-, 5-10 membered heteroaryl, and 5-10 membered heteroaryl-C1-8alkylene-;
• Ra is independently selected from:
• H, C1-8 alkyl, C3-8cycloalkyl, and C3-8 C1-8 alkylene-;
• and,
• Rb is independently selected from:
• H, C1-8 alkyl, C3-8 cycloalkyl, and C3-8 cycloalkyl-C1-8 alkylene-.