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US 9,067,940 B2Granted
Alicyclic derivatives of N,N'-substituted 3,7-diazabicyclo[3.3.1]nonanes and medicaments based thereon
OwnerMaxim Eduardovich Zapolsky, Nikolay Serafimovich Zefirov +2inventors
InventorsMaxim Eduardovich Zapolsky, Nikolay Serafimovich Zefirov, Vladimir Alexandrovich Palyulin, Mstislav Igorevich Lavrov
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Abstract
The invention relates to novel alicyclic N,N′-substituted diazabicyclo[3.3.1]nonane derivatives of general formula (I) which act as allosteric AMPA receptor modulators, and to drugs based thereon which can be used for treating Alzheimer's, Parkinson's and other neurodegenerative diseases.
Claims5
A compound of general formula 1, or a pharmacologically acceptable acid or salt thereof:
- wherein:
- E is a carbonyl group;
- R1 is H, C1-C6 alkyl or C1-C10 alkoxy;
- R2 is a group of general formula (1.1a):
- wherein:
- L is —C(HR15)— or a carbonyl group;
- R15 is H or C1-C6 alkyl;
- M is —NH— or a group with the general formula:
- —NH—(CHR15)m—, where m equals 0, 1, 2 or 3;
- or M is a valence bond;
- R3, R3′, R4, R4′, R5, R5′, R6, R6′, R7R7′, R8, R9, R10, R10′, R11, R11′, R12, R12′, R13, and R13′ are identical or different, and each independently is H, C1-C6 alkyl or C1-C10 alkoxy;
- X is a group with the general formula:
- where n equals 0, 1, 2 or 3,
- or X is a valence bond.
11 more elements
Dependencies are inferred from the claim text.