Bicyclic pyridinones

A compound having the structure of Formula I:

• wherein:
• X is a 5- to 14-membered heteroaryl containing 1-3 heteroatoms;
• R1 is hydrogen, halogen, C1-6alkyl;
• wherein said alkyl may be optionally and independently substituted with one to three of fluoro, cyano, —CF3, hydroxy, or C1-6alkoxy;
• R2a and R2b for each occurrence are each independently hydrogen, fluoro, cyano, —CF3, or C1-6alkyl;
• wherein said alkyl, may be optionally and independently substituted with cyano, C1-3alkyl or one to three fluoro;
• or R2a and R2b together with the carbon to which they are bonded form a 3- to 5-membered cycloalkyl optionally substituted with one to three R8;
• R3 is ) —(C(R11)2)t-(5- to 14-membered heteroaryl);
• wherein said heteroaryl moiety may be optionally independently substituted with one to five R10;
• R4a and R4b are each independently hydrogen, —CF3, or C1-6alkyl, wherein said alkyl is optionally substituted with one to three —CF3, cyano or fluoro;
• R5a and R5b for each occurrence are each independently hydrogen, —CF3, or C1-6alkyl, wherein said alkyl is optionally substituted with one to three —CF3, cyano or fluoro;
• R6, R7 and R8 are each independently hydrogen, —CF3, cyano, halogen, C1-6alkyl or —OR9;
• provided that R6 and R7 cannot both be —OH;
• R9 is hydrogen or, C1-6alkyl;
• wherein said alkyl may be optionally and independently substituted with cyano, or one to three fluoro;
• each R10 is independently hydrogen, halogen, cyano, —CF3, C1-6alkyl —(C(R11)2)m—OR12, —C(O)R13, —SF5 or —Si(CH3)3;
• wherein said alkyl, moieties may be optionally and independently substituted with one to three R14;
• each R11 is independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-4cycloalkyl, fluoro, —CF3, —CHF2 or —OR12;
• wherein said alkyl, alkenyl, alkynyl or cycloalkyl moieties may be optionally independently substituted with one to three fluoro or cyano;
• each R12 is independently hydrogen, C1-6alkyl, or —CF3;
• wherein said alkyl, may be optionally independently substituted with one to three R16;
• each R13 is independently C1-6alkyl;
• wherein said alkyl may be optionally independently substituted with one to three R16;
• each R14 is independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, halogen, cyano, —CF3, —CHF2, —OR9 or —OCF3;
• R16 is independently hydrogen, —CF3, cyano, halogen, C1-6alkyl or —OR9;
• wherein said alkyl moiety may be optionally substituted with one to three R17;
• R17 is independently hydrogen, hydroxyl, —CF3, cyano, fluoro, C2-6alkenyl or C2-6alkynyl;
• wherein said alkenyl or alkynyl moiety may be optionally substituted with one to three hydrogen, fluoro or C1-6alkyl;
• and
• each t or, m, is an integer independently selected from 0, 1, 2, 3 and 4;
• z is an integer selected from 1 and 2;
• y is an integer selected from 1, 2, 3 and 4;
• or a pharmaceutically acceptable salt thereof.