2-heteroaryl carboxamides

A method for improving memory in patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound represented by a compound of formula (I):

• wherein:
• R1 is 1-azabicyclo[2.2.2]oct-3-yl, which is optionally substituted via the nitrogen atom by a radical selected from the group of C1-C4-alkyl, benzyl and oxy,
• R2 is hydrogen or C1-C6-alkyl,
• R3 is hydrogen, halogen or C1-C6-alkyl,
• R4 is hydrogen, halogen, cyano, amino, trifluoromethyl, trifluoromethoxy, C1-C6-alkyl, C1-C6-alkylcarbonyl, C1-C6-alkylamino, formyl, hydroxycarbonyl, C1-C6-alkoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl, C1-C4-alkylsulphonylamino, C3-C8-cycloalkylcarbonylamino, C3-C6-cycloalkylaminocarbonyl, pyrrolyl, C1-C6-alkylaminocarbonylamino, hydroxyl, phenyl morpholinyl, oxypiperidinyl, oxopyrrolidinyl, oxomorpholinyl, pyrrolidinyl, morpholinylcarbonyl, piperidinyl, pyridinyl, dihydropyrrolylcarbonyl, C1-C6-alkylpiperizinylcarbonyl, isoxazolecarbonylamino, tetrahydrofuranylcarbonylamino, furoylamino, piperidinylcarbonyl, or piperidinylcarbonyl ,
• where C1-C6-alkyl may optionally be substituted by hydroxyl, cyano, amino, C1-C6-alkylaminocarbonylamino, C1-C6-alkylaminocarboxyl, morpholinyl or aryl,
• C1-C6-alkylaminocarbonyl may optionally be substituted by C1-C6-alkoxy or C1-C6-alkylamino, and
• C1-C6-alkylcarbonylamino may optionally be substituted by C1-C6-alkoxy,
• A is oxygen or sulphur,
• the ring B is benzo or pyrido, each of which are optionally substituted by radicals from the series halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-alkyl and C1-C6-alkoxy,
• and
• E is C≡C, phenylene, thienylene, oxadizolylene, pyrrolylene, furanylene, pyrimidinylene, or pyridinylene wherein each ring system respectively may be substituted by radicals from the series halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-C6-alkoxy and C1-C6-alkyl,
• or a salt thereof.