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US 9,067,894 B1Granted
Compound, composition, and method of activating GIRK potassium channel and use of same for treating conditions of interest
AssigneeVanderbilt University
InventorC. David Weaver
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Abstract
The present invention provides small molecule activators of GIRK potassium channels and methods for use thereof.
Claims18
A compound of the formula
- or a pharmaceutically-acceptable salt thereof, wherein R is selected from H, 2-Cl, 3-Cl, 4-Cl, 2-Br, 3-Br, 4-Br, 3-F, 4-F, 2-CF3, 3-CF3, 4-CF3, 3-CH3, 2-SCH3, 3-SO2NH2, 4-SO2NH2, 3-SCH3, 4-SCH3, 2-OCH3, 3-OCH3, 4-OCH3, 3,4-diCl, 3,5-diCl, 2-Cl/6-OCH3, and 3,4-diF.
A compound of the formula
- or a pharmaceutically-acceptable salt thereof,
- wherein R1 is selected from
- and
- R2 is selected from,
- and
- and
- R3 is selected from 3-Cl, 3-Br, 3-CH3, 4-CH3, 3-F, 4-F, 3, 4-diF, 3-SCH3, 3-CF3, and 3-Cl/4-F.
4 more elements
Dependencies are inferred from the claim text.