Inhibitors of protein kinases

A method for the treatment of pain, the method comprising administering to a subject in need of such treatment an effective amount of a compound of Formula (I):

• or a pharmaceutically acceptable salt, polymorph, tautomer and stereoisomer thereof wherein:
• Ra is H or methyl;
• R1 is selected from the group consisting of:
• carbocyclic or —C1-6 alkyl-carbocyclic, wherein the carbocyclic group is cyclohexyl or cyclopentyl;
• heterocyclic or —C1-6 alkyl-heterocyclic group, wherein the heterocyclic group is piperidine, piperazine, morpholine or pyrrolidine;
• aryl or alkyl-aryl;
• heteroaryl or —C1-6 alkyl-heteroaryl, wherein the heteroaryl group is pyridine, thiazole or thiophene;
• wherein any of the aforesaid carbocyclic, heterocyclic, aryl or heteroaryl groups may optionally be substituted by one or more groups independently selected from:
• halo, OH, NH2 and, for carbocyclic and heterocyclic groups, ═O;
• or
• C1-4 alkyl, —O(C1-4 alkyl), —NH(C1-4 alkyl), —NHC(O)(C1-4 alkyl), —S(C1-4 alkyl), —SO(C1-4 alkyl), —SO2(C1-4 alkyl) or —SO2NH(C1-4 alkyl) any of which may be further substituted with halo or OH;
• or
• R3, —C1-4 alkyl-R3, OR3, NHR3, —NHC1-4 alkyl-R3, —OC1-4 alkyl-R3, SR3, SOR3 or SO2R3;
• wherein R3 is an aryl, heteroaryl, carbocyclic or heterocyclic group any of which may be substituted with one or more halo, C1-4 alkyl, —O(C1-4 alkyl), NH2, —NH(C1-4 alkyl), —C(O)(C1-4 alkyl), —NHC(O)(C1-4 alkyl) groups, any of which alkyl groups may be substituted with halo or OH;
• each R2 is independently halo, OH, NH2;
• or
• C1-4 alkyl, —O(C1-4 alkyl), —NH(C1-4 alkyl), —C(O)(C1-4 alkyl), any of which may be further substituted with halo or OH;
• or
• R4, —C1-4 alkyl-R4, OR4, NHR4, alkyl-R4, —OC1-4 alkyl-R4, SR4, SOR4 or SO2R4;
• wherein R4 is an aryl, heteroaryl, carbocyclic or heterocyclic group any of which may be further substituted with one or more halo, OH, C14 alkyl, —O(C1-4 alkyl), NH2, —NH(C1-4 alkyl), —C(O)(C1-4 alkyl), —NHC(O)(C1-4 alkyl) groups, any of which alkyl groups may be substituted with halo or OH;
• and
• x is 0-4.