4-tolyl-ethynyl-octahydro-indole-1-ester derivatives

A compound of formula I

• wherein
• R1 is C1-4alkyl, C3-6cycloalkyl or C3-6cycloalkyl-C1-4alkyl;
• R2 and R3 independently are halogen, cyano, hydroxy, amino, C1-4alkyl;
• C1-4halogenalkyl;
• C1 -4hydroxyalkyl;
• C1-4aminoalkyl;
• C1-4alkylamino-C1-4alkyl;
• di-(C1-4alkyl)amino-C1-4alkyl;
• C1 -4alkoxy-C1-4alkyl;
• C2-4alkenyl;
• C2-4halogenalkenyl;
• C2-4alkinyl;
• C2-4halogenalkinyl;
• C1-4alkoxy;
• C1-4halogenalkoxy;
• C1-4alkyl-amino;
• di-(C1-4alkyl)amino or C3-6cycloalkyl, wherein one carbon atom of the C3-6cycloalkyl may be replaced by an oxygen atom and wherein the C3-6cycloalkyl may be attached directly to the ring system or via a C1-2alkylene or an oxygen;
• m is 0, 1, 2, 3, 4, 5 or 6;
• n is 0, 1, 2, 3 or 4;
• R4 and R5 independently are hydrogen, halogen or methyl;
• R6 is halogen, hydroxy, amino, cyano, methyl or methoxy;
• p is 0, 1, 2, 3 or 4;
• R7 is —C(O)R8;
• and
• R8 is C1-6alkyl which is substituted once or more than once by R12;
• and wherein each R12 is amino, morpholino, pyrrolidino, C1-6alkylamino or aminocarbonyl;
• in free form or in salt form.