Method for preparing difluoroacetonitrile and the derivatives thereof
AssigneeRhodia Operations
InventorOlivier Buisine
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Abstract
The present invention relates to a method for preparing difluoracetonitrile and the derivatives thereof. The method for preparing difluoroacetonitrile according to the invention is characterized in that it includes reacting halogenodifluoromethane and a source of cyanide anions in an alkaline medium. The invention also relates to the use of difluoroacetonitrile as an intermediate in the manufacture of difluoroacetic acid and the salts, esters, or amide thereof.
Claims21
A process for preparing difluoroacetonitrile, comprising a reaction of a halodifluoromethane and of a source of cyanide anions, in a basic aqueous medium.
A process for preparing a salt of difluoroacetic acid, comprising reacting a halodifluoromethane and a source of cyanide anions in a basic aqueous medium, in the presence of an amount of a base necessary both for carrying out a cyanation reaction and a hydrolysis reaction.
Dependencies are inferred from the claim text.