Method for loading amphiphile particles with active agents
AssigneeCamurus AB
InventorsFredrik Joabsson, Fredrik Tiberg, Markus Johnsson
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Abstract
The present invention provides a method for the production of amphiphile particles having incorporated therein at least one active agent. The method comprises forming a dispersion of particles comprising at least one amphiphilic structuring agent in a solution of at least one active agent, heating said dispersion to an elevated temperature, followed by cooling to around ambient temperature. The loading provided thereby is typically at least 130% of the loading provided by equilibration of the particles in a solution of active agent. The invention also provides corresponding amphiphile particles.
Claims7
A method for the production of amphiphile particles having incorporated therein at least one active agent, said method comprising
- (i) forming a dispersion of particles comprising at least one amphiphilic structuring agent and a solution of at least one active agent;
- (ii) heating said dispersion to a temperature in the range of 96° C. to 140° C.;
- and
- (iii) cooling to around ambient temperature thereby forming amphiphilic particles;
- wherein the active agent is incorporated into said particles to at least 130% of the maximum provided by a reference sample, wherein the reference sample is formed by equilibrating a dispersion of particles in a solution of at least one active agent at 37° C. for up to 3 days.
Dependencies are inferred from the claim text.